This interactive web application, which is based on the tables and protocols from the publication of E. de Vries et al Clin Exp Immunol 2012 Jan;167(1):108-19, will guide you through the various steps required for diagnosing primary immunodeficiencies (PIDs).

This web application is intended for healthcare professionals involved in diagnosing potential PIDs. It does not provide any recommendations on treatment of patients, but is just a tool in diagnosing PIDs, designed to guide healthcare professionals through the various steps for diagnosing PIDs. The healthcare professional remains responsible for the steps taken in this web application and for the diagnosis and treatment of the patient.

The web application starts with some basic details such as the patient’s gender, month and year of birth, the profession and country of the user of this application. After acceptance of the terms and conditions the interactive web application session will proceed and guide you along a dedicated path for diagnosing the patient concerned.

Table 1: Symptoms and signs that could point to potential PID includes clinical history, physical examination and baseline blood tests. You can select the symptoms of your patient. If the patient does not have any of the symptoms mentioned, choose: ‘none of the above’. Your selection will be registered by the database and will be printed on the final PDF.

Based on Table 2: Pattern of recognition gives direction to the diagnostic process eight clinical presentations are depicted. More background information of these clinical presentations can be found, as well as the suggested protocol to follow.

Within the protocols several steps can be taken resulting in a specific pattern that guides you through the diagnostic process. In the event that you need to stop and would like to continue later, you can use the ‘save patient button’. This will provide you with a link that you can use for the next visit to this website. You can choose to send this link to an email address. We recommend using solely your own email address. This email address will not be saved by the database and therefore cannot be used to send any emails, other than the email with the session link.

During the whole process you will find a summary listing all the steps taken during the session(s). After step 4: Final diagnosis there is an option to generate a PDF download. In this download a complete summary of the data input and steps taken is depicted. This can be included in the patient’s dossier.

The data generated by the web application will be analysed anonymously to provide further background information on PIDs. Data will only be used by De Vries et al. for scientific purposes such as presentations and/or peer-reviewed publications.